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MicroRNA That Shows Promise for Hair Regrowth

MicroRNA That Shows Promise for Hair Regrowth

Researchers Identify MicroRNA That Shows Promise for Hair Regrowth

Researchers from North Carolina State University have identified a microRNA (miRNA) that could promote hair regeneration. This miRNA – miR-218-5p – plays an important role in regulating the pathway involved in follicle regeneration and could be a candidate for future drug development.

Hair growth depends on the health of dermal papillae (DP) cells, which regulate the hair follicle growth cycle. Current treatments for hair loss can be costly and ineffective, ranging from invasive surgery to chemical treatments that don’t produce the desired result.

Recent hair loss research indicates that hair follicles don’t disappear where balding occurs, they just shrink. If DP cells could be replenished at those sites, the thinking goes, then the follicles might recover.

A research team led by Ke Cheng, Randall B. Terry, Jr. Distinguished Professor in Regenerative Medicine at NC State’s College of Veterinary Medicine and professor in the NC State/UNC Joint Department of Biomedical Engineering, cultured DP cells both alone (2D) and in a 3D spheroid environment. A spheroid is a three-dimensional cellular structure that effectively recreates a cell’s natural microenvironment.

In a mouse model of hair regeneration, Cheng looked at how quickly hair regrew on mice treated with 2D cultured DP cells, 3D spheroid-cultured DP cells in a keratin scaffolding, and the commercial hair loss treatment Minoxidil. In a 20-day trial, mice treated with the 3D DP cells had regained 90% of hair coverage at 15 days.

“The 3D cells in a keratin scaffold performed best, as the spheroid mimics the hair microenvironment and the keratin scaffold acts as an anchor to keep them at the site where they are needed,” Cheng says. “But we were also interested in how DP cells regulate the follicle growth process, so we looked at the exosomes, specifically, exosomal miRNAs from that microenvironment.” Exosomes are tiny sacs secreted by cells that play an important role in cell to cell communication. Those sacs contain miRNAs.

MiRNAs are small molecules that regulate gene expression. Cheng and his team measured miRNAs in exosomes derived from both 3D and 2D DP cells. In the 3D DP cell-derived exosomes, they pinpointed miR-218-5p, a miRNA that enhances the molecular pathway responsible for promoting hair follicle growth. They found that increasing miR-218-5p promoted hair follicle growth, while inhibiting it caused the follicles to lose function.

“Cell therapy with the 3D cells could be an effective treatment for baldness, but you have to grow, expand, preserve and inject those cells into the area,” Cheng says. “MiRNAs, on the other hand, can be utilized in small molecule-based drugs. So potentially you could create a cream or lotion that has a similar effect with many fewer problems. Future studies will focus on using just this miRNA to promote hair growth.”

The research appears in Science Advances, and was supported by the National Institutes of Health and the American Heart Association. Cheng is corresponding author. Postdoctoral researcher Shiqi Hu is first author.

-peake-

“Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling”

DOI: 10.1126/sciadv.aba1685

Authors: Shiqi Hu, Zhenhua Li, Halle Lutz, Teng Su, Ke Cheng, North Carolina State University College of Veterinary Medicine and the NC State/UNC Joint Department of Biomedical Engineering; Ke Huang, Jhon Cores, Phuong-Uyen Cao Dinh, North Carolina State University College of Veterinary Medicine

Published: July 24, in Science Advances

Abstract: The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment.

Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes down-regulated the secreted frizzled-related protein 2 and up-regulated β-catenin, promoting the development of hair follicles.

Researchers Identify MicroRNA That Shows Promise for Hair Regrowth

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MicroRNA That Shows Promise for Hair Regrowth

MicroRNA That Shows Promise for Hair Regrowth

Researchers Identify MicroRNA That Shows Promise for Hair Regrowth

Researchers from North Carolina State University have identified a microRNA (miRNA) that could promote hair regeneration. This miRNA – miR-218-5p – plays an important role in regulating the pathway involved in follicle regeneration and could be a candidate for future drug development.

Hair growth depends on the health of dermal papillae (DP) cells, which regulate the hair follicle growth cycle. Current treatments for hair loss can be costly and ineffective, ranging from invasive surgery to chemical treatments that don’t produce the desired result.

Recent hair loss research indicates that hair follicles don’t disappear where balding occurs, they just shrink. If DP cells could be replenished at those sites, the thinking goes, then the follicles might recover.

A research team led by Ke Cheng, Randall B. Terry, Jr. Distinguished Professor in Regenerative Medicine at NC State’s College of Veterinary Medicine and professor in the NC State/UNC Joint Department of Biomedical Engineering, cultured DP cells both alone (2D) and in a 3D spheroid environment. A spheroid is a three-dimensional cellular structure that effectively recreates a cell’s natural microenvironment.

In a mouse model of hair regeneration, Cheng looked at how quickly hair regrew on mice treated with 2D cultured DP cells, 3D spheroid-cultured DP cells in a keratin scaffolding, and the commercial hair loss treatment Minoxidil. In a 20-day trial, mice treated with the 3D DP cells had regained 90% of hair coverage at 15 days.

“The 3D cells in a keratin scaffold performed best, as the spheroid mimics the hair microenvironment and the keratin scaffold acts as an anchor to keep them at the site where they are needed,” Cheng says. “But we were also interested in how DP cells regulate the follicle growth process, so we looked at the exosomes, specifically, exosomal miRNAs from that microenvironment.” Exosomes are tiny sacs secreted by cells that play an important role in cell to cell communication. Those sacs contain miRNAs.

MiRNAs are small molecules that regulate gene expression. Cheng and his team measured miRNAs in exosomes derived from both 3D and 2D DP cells. In the 3D DP cell-derived exosomes, they pinpointed miR-218-5p, a miRNA that enhances the molecular pathway responsible for promoting hair follicle growth. They found that increasing miR-218-5p promoted hair follicle growth, while inhibiting it caused the follicles to lose function.

“Cell therapy with the 3D cells could be an effective treatment for baldness, but you have to grow, expand, preserve and inject those cells into the area,” Cheng says. “MiRNAs, on the other hand, can be utilized in small molecule-based drugs. So potentially you could create a cream or lotion that has a similar effect with many fewer problems. Future studies will focus on using just this miRNA to promote hair growth.”

The research appears in Science Advances, and was supported by the National Institutes of Health and the American Heart Association. Cheng is corresponding author. Postdoctoral researcher Shiqi Hu is first author.

-peake-

“Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling”

DOI: 10.1126/sciadv.aba1685

Authors: Shiqi Hu, Zhenhua Li, Halle Lutz, Teng Su, Ke Cheng, North Carolina State University College of Veterinary Medicine and the NC State/UNC Joint Department of Biomedical Engineering; Ke Huang, Jhon Cores, Phuong-Uyen Cao Dinh, North Carolina State University College of Veterinary Medicine

Published: July 24, in Science Advances

Abstract: The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment.

Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes down-regulated the secreted frizzled-related protein 2 and up-regulated β-catenin, promoting the development of hair follicles.

Researchers Identify MicroRNA That Shows Promise for Hair Regrowth

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Aesthetics Treatments for Body Improvement

Aesthetics Treatments for Body Improvement

ABM Launches Three Medical Procedures Aesthetics Treatments for Body Improvement

ABM Medical Clinic & Cosmetics, a top-rated clinic for body improvements and facial aesthetics, is proud to announce the addition of three new aesthetic medical procedures. The new body rejuvenation treatments include PRP (Platelet-Rich Plasma) Facial, PRP Therapy for Hair Loss, and Vampire Facial.

Our PRP Facial cosmetic procedure helps tighten the skin and quickens the healing process. Whether wrinkles, age spots, scarring, or hyperpigmentation, our team of board-certified physicians uses a minimally invasive treatment to remove scars, improve skin tone and texture, boost collagen and elastin, and rejuvenate the skin.

We combine both traditional micro needling and modern collagen induction therapy to improve effects and achieve faster results. Our PRP facial procedure is proven to be safe with no chance for allergic reactions because the plasma comes from your own body.

In addition, ABM Medical Clinic & Cosmetic is happy to introduce an innovative hair loss treatment.

Our PRP Hair Loss medical procedure is a product of years of consistently exploring the best options for hair loss solutions. This three-step medical hair restoration procedure uses PRP to trigger healthy hair growth in dying hair follicles.

It also increases the thickness of the hair shaft, helping you revitalize natural hair. Our hair restoration strategy is for women and men seeking the best alternative to hair transplant surgery by appropriately fixing hair loss.

We have also added a nonsurgical cosmetic procedure called Vampire Facial to help men and women offset ageing effects like hollowed-out skin, crow’s feet, bumps, and certain skin deformities. Our Vampire Facial clinical procedure uses cellular therapy to rejuvenate the skin and provide a youthful, natural, and healthy appearance without the need for plastic surgery. It is a non-invasive cosmetic procedure that requires only topical anaesthesia.

We are committed to providing you with the healthiest skin and body, keeping you in the best physical state regardless of age. For more information about our process and to book a free consultation:

ABM Launches Three Medical Procedures Aesthetics Treatments for Body Improvement

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Anti-dandruff Agent Additive Market

Anti-dandruff Agent Additive Market

Global Anti-dandruff Agent Additive Market Insights and Forecast to 2027

Market Analysis and Insights: Global Anti-dandruff Agent Additive Market

The global Anti-dandruff Agent Additive market size is projected to reach US$ XX million by 2027, from US$ XX million in 2020, at a CAGR of XX% during 2021-2027.

Global Anti-dandruff Agent Additive Scope and Segment

Anti-dandruff Agent Additive market is segmented by Type, and by Application. Players, stakeholders, and other participants in the global Anti-dandruff Agent Additive market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on production capacity, revenue and forecast by Type and by Application for the period 2016-2027.

The following manufacturers are covered in this report:

Clariant AG

Aurora Chemical

Spec Chem Group

Kumar Organic

Chemspec Chemicals

3C Pharmchem

Somu Group

Kolon Life Science

Regen Chemical

Symrise

Tinci Materials

Seqens SAS

Merck KGaA

Plater Group

Gaopeng Pharmaceutical

Kavya Pharma

Fengchen Technology

Xi’an Taicheng Chem

Anti-dandruff Agent Additive Breakdown Data by Type

Piroctone Olamine

Climbazole

Slaicylic Acid

Ketoconazole

Coal Tar

Selenium Sulfide

Other

Anti-dandruff Agent Additive Breakdown Data by Application

Personal Care

Pharmaceutical

Regional and Country-level Analysis

The Anti-dandruff Agent Additive market is analysed and market size information is provided by regions (countries).

The key regions covered in the Anti-dandruff Agent Additive market report are North America, Europe, China and Japan. It also covers key regions (countries), viz, the United States, Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Mexico, Brazil, Turkey, Saudi Arabia, UAE, etc.

The report includes a country-wise and region-wise market size for the period 2016-2027. It also includes market size and forecast by Type, and Application segment in terms of production capacity, price and revenue for the period 2016-2027.

Global Anti-dandruff Agent Additive Market Insights and Forecast to 2027

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Hair Products Cause Hair Loss

Hair Products Cause Hair Loss

Johnson & Johnson Hair Products Cause Hair Loss, Lawsuit Claims

A class-action lawsuit has been filed against Johnson & Johnson with the claim that the company’s OGX hair care products cause significant hair loss.

The products are sold at major national retailers, including Target, Ulta, CVS, Walmart, and Walgreens. Johnson & Johnson shampoos, conditioners, and some hair oils are among the products named in the lawsuit.

The plaintiff, Larissa Whipple, an Illinois woman, cites the ingredient DMDM hydantoin as the main concern. DMDM hydantoin is a preservative and antimicrobial agent sometimes found in hair care products. It’s considered a “formaldehyde donor,” meaning it releases a small amount of formaldehyde overtime to keep the product fresh.

But formaldehyde donors like this one have been linked to allergies, rashes, hair loss, and cancer. The Department of Health and Human Services’ National Toxicology Program has said formaldehyde is known to cause cancer.

The lawsuit says that the company may have violated consumer protection laws by advertising the products containing this ingredient to people who want healthy hair.

“Johnson & Johnson made a number of affirmative misrepresentations … that the products ‘deeply nourish’, ‘gently cleanse,’ and ‘repair hair.’ However, the products’ formula contains an ingredient, or combination of ingredients, that has caused Plaintiff and thousands of consumers to experience hair loss and/or scalp irritation,” the lawsuit says.

Johnson & Johnson says all their ingredients are carefully selected and are listed on the products’ label. The company stated that none of their new products contains DMDM hydantoin and they have not launched any new hair products with this ingredient in several years.

“We carefully select ingredients to ensure the safety and performance of our products,” Johnson & Johnson said in a statement to WebMD. “Some of our existing products contain a small amount of DMDM hydantoin, which is used to prevent mould from developing while the product is in the shower. Every preservative used in our products must clear our rigorous safety assessment process.”

In August 2012, Johnson & Johnson announced it would remove DMDM hydantoin and other similar ingredients from their products by 2015. However, the lawsuit says that is a “broken promise.”

“Johnson & Johnson did in fact remove DMDM hydantoin from existing consumer products at that time,” the lawsuit says. “However, when Johnson & Johnson acquired Vogue International, including their line of OGX products, Johnson & Johnson failed to change the ingredient profile of the products that did not maintain the same standards for consumer safety.”

In the preservatives section of Johnson & Johnson’s safety and care commitment website, the company claims DMDM hydantoin does not meet their safety standards, but further down the page they say they use DMDM hydantoin in products when other preservatives are incompatible with other ingredients in a formula.

Dermatologist Shani Francis, MD, says hair product manufacturers should be striving to create a positive experience for their customers.

“Hair breakage and texture changes are important clues to pay attention to regarding overall hair health. We should always seek out products to enhance our hair care experience,” Francis says. “Having a great understanding of your individual hair needs is most important to avoid problems.”

DMDM hydantoin is listed by the FDA as one of the preservatives found to cause the most allergic reactions from the use of cosmetic products. The FDA requires certain products to list ingredients, but some ingredients may not be specifically identified and instead listed as “fragrance” or “perfume.”

Francis says an important thing to remember is that there is no “one size fits all” for hair care products and seeking out products with a company history of strong customer experience is a good way to look for new products.

“For ingredients, water-based products are generally a good place to start. Aloe vera high in the ingredient list suggests a more acidic pH. Glycerin also is a humectant that can help naturally add moisture to the hair,” Francis says. “Ultimately, balance is most important. Often[times], too much of a good thing is not a good thing. Additionally, if you have an underlying medical, scalp or skin condition, you could have a unique situation and should seek the help of a board-certified dermatologist.”

Johnson & Johnson Hair Products Cause Hair Loss, Lawsuit Claims

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Scalp Microneedling Market

Scalp Microneedling Market

2021-2027 Global Scalp Microneedling Market Report – Production and Consumption Professional Analysis (Impact of COVID-19)

Description_

This report elaborates the market size, market characteristics, and market growth of the Scalp Microneedling industry, and breaks it down according to the type, application, and consumption area of Scalp Microneedling.

The report also conducted a PESTEL analysis of the industry to study the main influencing factors and entry barriers of the industry.

In Chapter 3.4 of the report, the impact of the COVID-19 outbreak on the industry was fully assessed. Fully risk assessment and industry recommendations were made for Scalp Microneedling in a special period. This chapter also compares the markets of Pre COVID-19 and Post COVID-19.

In addition, chapters 8-12 consider the impact of COVID-19 on the regional economy.

Key players in the global Scalp Microneedling market covered in Chapter 13

Lotus
Yonghe Hair Transplant
zcalp

In Chapter 6, on the basis of types, the Scalp Microneedling market from 2015 to 2025 is primarily split into:

Under 0.25 mm
25mm-0.3mm
75mm-1.0mm
1.0mm-1.5mm
Above 1.5mm

In Chapter 7, on the basis of applications, the Scalp Microneedling market from 2015 to 2025 covers:

Hair Transplant
Boost Hair
Others

Geographically, the detailed analysis of production, trade of the following countries is covered in Chapter 4.2, 5

United States
Europe
China
Japan
India

Geographically, the detailed analysis of consumption, revenue, market share and growth rate of the following regions are covered in Chapters 8, 9, 10, 11, 12

North America (Covered in Chapter 8)
United States
Canada
Mexico
Europe (Covered in Chapter 9)

The Middle East and Africa (Covered in Chapter 11)

Years considered for this report:

Historical Years: 2015-2019
Base Year: 2019
Estimated Year: 2020
Forecast Period: 2020-2025

2021-2027 Global Scalp Microneedling Market Report – Production and Consumption Professional Analysis (Impact of COVID-19)

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Radical New Way to Treat Baldness

Radical New Way to Treat Baldness

Hair Follicles Can Smell Sandalwood, And It Could Be a Radical New Way to Treat Baldness

We tend to imagine smells as things that just float around us in the air, but there’s more to it than that.

What we perceive as the smell is actually an intersection between molecules called odorants (or aroma compounds) and olfactory receptors that are expressed by cells in our body, which send a signal to the brain when activated.

That whole process, in a nutshell, is the smell. But it turns out it’s not just our noses that can do it.

New research shows that human hair follicles express an olfactory receptor of their own called OR2AT4, and when OR2AT4 comes into contact with the molecular structure of a specific scent –synthetic sandalwood, as it turns out – it stimulates hair growth.

In other words, your hair – or rather your hair follicles – can ‘smell’, and if they sniff out the right chemical, it could be a radical new way of preventing hair loss.

“This is actually a rather amazing finding,” senior researcher and dermatologist Ralf Paus from the University of Manchester in the UK told The Independent.

“This is the first time ever that it has been shown that the remodelling of a normal human mini-organ [a hair] can be regulated by a simple, cosmetically widely-used odorant.”

Scientists already knew that OR2AT4 could be leveraged to promote keratinocyte proliferation in the skin (which promotes wound healing), leading Paus and his team to wonder whether olfactory receptors could be manipulated to also boost hair growth.

To find out, the researchers took samples of human scalp skin – donated by patients undergoing face-lift operations – and treated them with an application of synthetic sandalwood (aka Sandalore) in the lab.

Unlike authentic sandalwood, which doesn’t bind to OR2AT4, the team found synthetic sandalwood – used in personal care products to provide a sandalwood scent – does bind with the receptor, regulating expression and secretion of a key hair growth-promoting factor called IGF–1.

In other words, by promoting IGF–1, synthetic sandalwood stimulates the growing phase of hair cells, while helping to prevent them from dying.

When another chemical called Phenirat was mixed in to silence OR2AT4, it inhibited hair growing, suggesting the receptor plays a bigger part in hair growth than scientists previously knew.

The research was funded in part by an Italian pharmaceutical company that sells Sandalore in its products – which is something to bear in mind in light of the results.

But because of this pre-existing commercial availability of synthetic sandalwood, the team thinks their “olfactotherapy” discovery could end up helping patients sooner rather than later, if further clinical trials pan out.

According to Paus, the early signs of ongoing research are promising.

“A very small, short and preliminary clinical pilot study performed by an independent CRO [contract research organisation] in 20 female volunteers with topical Sandalore has already suggested a reduction of daily hair loss,” he says.

The next step is to see if that result can be replicated in a larger clinical trial, which the researchers hope to conclude in January next year.

We can’t get too carried away until we see what future tests bring, but according to Nicola Clayton of the British Association of Dermatologists, the initial data look exciting.

“It is a fascinating concept that the human hair follicle, as the authors put it, can ‘smell’ by utilising an olfactory receptor,” she told The Independent.

We’ll have to wait to see where this research leads from here, but if the team’s next trial is a success, we could be looking at an important new mechanism for hair loss prevention here.

Hair Follicles Can ‘Smell’ Sandalwood, And It Could Be a Radical New Way to Treat Baldness

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Stem Cell and Platelet Rich Plasma (PRP) Alopecia

Stem Cell and Platelet Rich Plasma Alopecia

2021-2027 Global and Regional Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies

The research team projects that the Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies market size will grow from XXX in 2020 to XXX by 2027, at an estimated CAGR of XX. The base year considered for the study is 2020, and the market size is projected from 2020 to 2027.

The prime objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing with 10 major regions and 50 major countries.

Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts.

The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

By Market Players:

Orange County Hair Restoration Center
Colorado Surgical Center & Hair Institute
Evolution Hair Loss Institute
Hair Sciences Center of Colorado
Hair Transplant Institute of Miami
Anderson Center for Hair
Virginia Surgical Center
Savola Aesthetic Dermatology Center

By Type

Platelet Rich Plasma Injections
Stem Cell Therapy

By Application

Dermatology Clinics
Hospitals

By Regions/Countries:

North America
United States
Canada
Mexico
East Asia
China
Japan
South Korea
Europe
Germany
United Kingdom
France
Italy
Russia
Spain
Netherlands
Switzerland
Poland
South Asia
India
Pakistan
Bangladesh
Southeast Asia
Indonesia
Thailand
Singapore
Malaysia
Philippines
Vietnam
Myanmar
Middle East
Turkey
Saudi Arabia
Iran
United Arab Emirates
Israel
Iraq
Qatar
Kuwait
Oman
Africa
Nigeria
South Africa
Egypt
Algeria
Morocoo
Oceania
Australia
New Zealand
South America
Brazil
Argentina
Colombia
Chile
Venezuela
Peru
Puerto Rico
Ecuador
Rest of the World
Kazakhstan

Points Covered in The Report

The points that are discussed within the report are the major market players that are involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors and etc.

The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. This report analyzed 12 years of data history and forecast.

The growth factors of the market is discussed in detail wherein the different end users of the market are explained in detail.

Data and information by market player, by region, by type, by application and etc, and custom research can be added according to specific requirements.

The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

Key Reasons to Purchase

To gain insightful analyses of the market and have a comprehensive understanding of the global market and its commercial landscape.

Assess the production processes, major issues, and solutions to mitigate the development risk.

To understand the most affecting driving and restraining forces in the market and their impact on the global market.

Learn about the market strategies that are being adopted by leading respective organizations.

To understand the future outlook and prospects for the market.

Besides the standard structure reports, we also provide custom research according to specific requirements.

The report focuses on Global, Top 10 Regions and Top 50 Countries Market Size of Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies 2016-2021, and development forecast 2022-2027 including industries, major players/suppliers worldwide and market share by regions, with the company and product introduction, position in the market including their market status and development trend by types and applications which will provide its price and profit status, and marketing status & market growth drivers and challenges, with the base year as 2020.

Key Indicators Analysed

Market Players & Competitor Analysis: The report covers the key players of the industry including Company Profile, Product Specifications, Production Capacity/Sales, Revenue, Price and Gross Margin 2016-2021 & Sales by Product Types.

Global and Regional Market Analysis: The report includes Global & Regional market status and outlook 2022-2027. Further the report provides break down details about each region & countries covered in the report.

Identifying its production, consumption, import & export, sales volume & revenue forecast.

Market Analysis by Product Type: The report covers the majority of Product Types in the Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies Industry, including its product specifications by each key player, volume, sales by Volume and Value (M USD).

Market Analysis by Application Type: Based on the Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies Industry and its applications, the market is further sub-segmented into several major Applications of its industry. It provides you with the market size, CAGR & forecast by each industry application.

Market Trends: Market key trends include Increased Competition and Continuous Innovations.

Opportunities and Drivers: Identifying the Growing Demands and New Technology

Porters Five Force Analysis:

The report will provide the state of competition in the industry depends on five basic forces: the threat of new entrants, bargaining power of suppliers, bargaining power of buyers, the threat of substitute products or services, and existing industry rivalry.

COVID-19 Impact

The report covers Impact of Coronavirus COVID-19: Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost every country around the globe with the World Health Organization declaring it a public health emergency.

The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies market in 2021. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor/outdoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future.

2021-2027 Global and Regional Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies

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Global Dandruff Treatment Market

Global Dandruff Treatment Market

Global Dandruff Treatment Market

Market Analysis and Insights: Global Dandruff Treatment Market

The dandruff treatment market is expected to gain market growth in the forecast period of 2021 to 2028. Data Bridge Market Research analyses that the market is growing with a CAGR of 5.8% in the forecast period of 2021 to 2028 and is expected to reach USD 11.915.15 million by 2028 from USD 7,645.23 million in 2020.

Increasing awareness regarding the scalp condition and growing urbanization, availability of various dandruff treatment substitutes is the key driver of the market for global dandruff treatment market.

Dandruff is a scalp issue that is recognized by the presence of corneocytes that have the ability to shape groups. These bunches are white to yellowish scales and cause tingling at influenced zone. Dandruff generally influences during adolescence to middle age stage as this is the stage when sebaceous organs are at an exceptionally dynamic stage. There are different causes related to dandruff in which Malassezia furfur, a growth turns into the ruling element. Also, bacterial development over the scalp harms the scalp layer corneum.

Dandruff treatment products hence target these microbes in several ways. Zinc pyrithione is used in most of anti-dandruff products as it has anti-fungal activity. The other antifungal drugs indicated for dandruff treatment are ketoconazole, climbazole, selenium sulphide among others. Herbal products used for dandruff treatment are herbal oils that include tea tree oils, rosemary oil, lemon oil, neem, basil, cedar wood among others.

The demand for dandruff treatment has been increased in both developed as well as in developing countries and the reason behind this is the increasing number of Malassezia species in the environment. The dandruff treatment market is growing due to the introduction of innovative products, increasing e-commerce of hair care products and rising disposable income. The market will grow in the forecasted period due to exploration of emerging markets, strategic initiatives by market players and increasing awareness regarding hair problems.

The dandruff treatment market report provides details of market share, new developments, and product pipeline analysis, impact of domestic and localised market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, product approvals, strategic decisions, product launches, geographic expansions, and technological innovations in the market. To understand the analysis and the market scenario contact us for an Analyst Brief, our team will help you create a revenue impact solution to achieve your desired goal.

Global Dandruff Treatment Market Scope and Market Size

The global dandruff treatment market is categorized into eight notable segments which are based on basis of type, mode of prescription, product, drug type, age group, gender, end-user and distribution type.

  • On the basis of type, the dandruff treatment market is segmented into fungal dandruff, dry skin-related dandruff, oily scalp-related dandruff, disease-related dandruff. In 2021, fungal dandruff is dominating the market as a fungus called Malassezia is considered to be the main cause of dandruff. Although dandruff can be caused by several simultaneous reasons, the level of a fungus is one of the strongest contributing factors. A large number of dandruff treatment products are aimed at restoring the microbiome of the scalp and hence controlling the fungus.
  • On the basis of mode of prescription, the dandruff treatment market is segmented into OTC, prescriptions. In 2021, OTC mode is dominating the market as most of the dandruff treatment products can be used at home without any prescription. These products are used over the skin and do not enter the body, making them safe for self-supervision. The easy availability of these products also attributes to the high share of OTC products in the dandruff treatment market.
  • On the basis of product, the dandruff treatment market is segmented into non-medicated, medicated. In 2021, non-medicated products are dominating in the global dandruff treatment market as more than 50% of adults are affected by this transient condition that does not cause any significant medical conditions. Most of the products for dandruff treatment are available over-the-counter and prove effective in controlling the symptoms.
  • On the basis of drug type, the dandruff treatment market is segmented into branded, generics. In 2021, branded products are dominating the global dandruff treatment market as most of the products constitute shampoos and oils manufactured by well-known global companies. Due to significant product promotion, consumer awareness is very high for several products making the branded products more common.
  • On the basis of age group, the dandruff treatment market is segmented into adults, paediatrics, neonates. In 2021, adults are dominating in the global dandruff treatment market as dandruff affects 50% of adults over different time periods primarily due to fungus infection, dry scalp and sebum production. Moreover, the number of adults affected by dandruff is very high as compared to pediatrics and neonates. Hence, adults are the primary users of dandruff treatment products.
  • On the basis of gender, the dandruff treatment market is segmented into male, female. In 2021, the male population is dominating in the global dandruff treatment market as in addition to fungus and dryness, higher sebum levels are also associated with the condition. Hence, more men are affected with dandruff as compared to women. This can be attributed to the changes in the activity of the sebaceous (oil) glands in the skin, such as the hike in sebum production around adolescence, increasing its likelihood.
  • On the basis of end-user, the dandruff treatment market is segmented into home care, dermatology centres, speciality clinics, others. In 2021, homecare is dominating in the global dandruff treatment market due to the self-administration nature of most products. The symptoms are easily recognizable and not medically detrimental. Hence, affected individuals tend to take care of themselves in most cases.
  • On the basis of distribution type, the dandruff treatment market is segmented into supermarkets/hypermarkets, convenience stores, pharmacies, retail stores, online stores, others. In 2021, supermarkets /hypermarkets are dominating the market as the sources of the highest sales of consumer products. These establishments have large varieties of dandruff treatment products ranging from simplest products to premium products and the consumer can choose as per requirement. As a result, consumers prefer supermarkets /hypermarkets due to the availability of choices.

Dandruff Treatment Market Country Level Analysis

The dandruff treatment market is analysed and market size information is provided by type, mode of prescription, product, drug type, age group, gender, end-user and distribution type.

The countries covered in the dandruff treatment market report are the U.S., Canada, Mexico, Germany, France, U.K., Italy, Spain, Russia, Poland, Turkey, Switzerland, Netherlands, Belgium, Hungary, Austria, Norway, Ireland, Lithuania, Rest of Europe, China, Japan, India, Australia, South Korea, Singapore, Thailand, Malaysia, Indonesia, Philippines, Vietnam, Rest of Asia-Pacific, Brazil, Argentina, Peru, Rest of South America, South Africa, Saudi Arabia, UAE, Israel, Egypt and Rest of Middle East and Africa.

The U.S. in North America has the highest household spending in the world and offers trade agreements with several countries making it the largest market for consumer products including dandruff treatment products. China is expected to dominate in the market in the Asia-Pacific market. China is one of the leading countries in the world with rapidly increasing product usage and treatment rate with rising awareness regarding Malassezia species. Germany in Europe is expected to grow with the most promising growth rate in the forecast period of 2021 to 2028 with changing lifestyles and growing urbanization.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impact the current and future trends of the market. Data points such as new sales, replacement sales, country demographics, regulatory acts and import-export tariffs are some of the major pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, the impact of sales channels are considered while providing forecast analysis of the country data.

Strategic Initiatives by manufacturers is Creating New Opportunities for Players in the Dandruff Treatment Market

The dandruff treatment market also provides you with detailed market analysis for every country growth in the aesthetic industry with dandruff treatment product sales, the impact of advancement in the dandruff treatment and changes in regulatory scenarios with their support for the dandruff treatment market. The data is available for the historic period 2010 to 2018.

Competitive Landscape and Dandruff Treatment Market Share Analysis

Dandruff treatment market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, production sites and facilities, company strengths and weaknesses, product launch, product trials pipelines, product approvals, patents, product width and breadth, application dominance, technology lifeline curve. The above data points provided are only related to the company’s focus related to the dandruff treatment market.

The major companies providing dandruff treatment are Alliance Pharma PLC, Arcadia Consumer Healthcare, Vyome Therapeutics Inc., ACTICON LIFE SCIENCES, JOHN PAUL MITCHELL SYSTEMS, Johnson & Johnson Consumer Inc. (A Subsidiary of Johnson & Johnson Services, Inc.), JĀSÖN Natural Products, Inc. (A Subsidiary of Hain Celestial), Cipla Inc., Nikole Kozemetics, PHYTO, DABUR, Glenmark Pharmaceuticals Limited, Kao Corporation, L’OCCITANE EN PROVENCE INTERNATIONAL SA. (A Subsidiary of Groupe L’OCCITANE), PROCTER & GAMBLE, Philip Kingsley Products Ltd., Unilever, HENKEL AG & CO. KGAA, L’OREAL S.A., SOVEREIGN CHEMICALS & COSMETICS, M.M. AYURVEDIC (P) LTD., Arion Healthcare, Viencee Cosmatics, Sebapharma, AVON Beauty Products India Pvt Ltd, among others among other domestic and global players. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

Many product launches and agreements are also initiated by the companies worldwide which are also accelerating the dandruff treatment market.

  • In February 2019, Dabur launched two new products in the existing product portfolio of hair care products. This new product found enhanced the company’s product portfolio and boosted the company’s revenue.

Collaboration, joint ventures and other strategies by the market player is enhancing the company market in the dandruff treatment market which also provides the benefit for the organisation to improve their offering for dandruff treatment market.

Global Dandruff Treatment Market

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shampoo

Shampoo Market Type

Shampoo Market Type

Shampoo has become an essential part of the basic hair care regime and this is the major factor that boosts its demand in the market. From general hair cleansing to professional hair treatment, shampoos have been getting highly diversified catering to specific groups or needs.

The key market players keep recognizing the needs and desires of the consumer base and hence develop products accordingly to cater to different requirements of the customers.

The growing health concerns make consumers particular regarding their choices and hence the market gets diversified. The advantageous features of the product continue to boost the market demand

Market scope and structure analysis:

Market size available for years

2020–2027

Base year considered

2019

Forecast period

2021–2027

Forecast units

Value ($US)

Segments covered

Type, Application, Distribution Channel, Industry Vertical, and Region

Regions covered

North America (U.S., Canada and Mexico), Europe (Germany, UK, France, Italy, Spain and Rest of Europe), Asia-Pacific (China, Japan, India, Australia, Malaysia, Thailand, Indonesia, and Rest of Asia-Pacific), LAMEA (Middle East, Brazil and Rest of LAMEA)

Companies covered

L’Oréal S.A., Unilever plc, The Procter & Gamble Company, Neutogena, Shiseido Company Limited, Church and Dwight Co., Henkel AG & Co., Kimberly Clark Corporation, The Estée Lauder Companies Inc., Amway Corporation.

COVID-19 Scenario Analysis:

Production shut down

The production for the industry has been shut down as a precautionary measure from coronavirus. This has impacted the revenue for the firm.

Disrupted supply chains

The production and supply is abruptly disrupted amid the coronavirus outbreak. This is affecting the sales and revenue ofthe company. The offline stores have been operating at a slower pace but the industry is expected to revive soon after the resettlement of the situation.

Top Impacting Factors: Market Scenario Analysis, Trends, Drivers, and Impact Analysis

The global shampoo market is in the upward swing in light of rising in the predominance of diseases or hair implications identified with hair, for example, dandruff, hair fall, slick hair, and dryness of the hair, irritation, and numerous others. Developing urbanization, expanding per capita salary, and change in lifestyle are the significant factors that drive the growth of the global shampoo market. Customer awareness about the individual customization and cleanliness, accessibility of different types of shampoos through various kinds of dissemination, and aggressive advertising from the key marketers about the advantages of utilizing
their product fosters the growth of the shampoo industry.

The global shampoo market trends are as follows:

New product launches to flourish the market

An increase in diversification in the demands from the consumer and application of the product make way for ample opportunities for the key players to diversify their products and expand their businesses. Hence, the market is steady with numerous products that provide hair condition features, capability of hair fall reduction, anti-dandruff and herbal products, and others.

This is because the market consists of personal care products and hence their demand is highly personalized. Consumers develop preferences and loyalty for a brand and then continue to expect improvements in the same product. This has led to the production of many variants within the same product and a choice range to consumers to pick whatever suits their needs the most. Also, a product that caters to multiple consumer needs appears to be the most admired product.

Diversification in the distribution channel

Manufacturers have always been promoting the products in such a way that a consumer not just wishes to purchase it but is also able to buy the product at his/her own convenience. As such, the product needs to be supplied to the consumer market so that there is no lack of supply in the market and quick revenue could be converted from the same.

Since shampoos have been highly used as personal care and hygiene products on a regular basis in daily lives, it becomes prominent to make the product available to the customer. For this, the markets have opted from various distribution channels including offline stores such as supermarkets, departmental stores, and specialist retailers and online web stores such as Amazon.com, Walmart, and others. These multi-platform channels enable the product to reach the masses and cater to consumer convenience.

Key Segments Covered:

              Segments

                                  Sub-segments

  Type

  • 2-in-1 Shampoo
  • Anti-Dandruff
  • Kids Shampoo
  • Medicated Shampoo
  • Standard Shampoo
  • Others

  Application

  • Residential
  • Commercial
  • Others

  Distribution Channel

  • Supermarkets/Hypermarkets
  • Convenience Stores
  • Specialist Retailers
  • Drug Stores &Pharmacies
  • Online Stores
  • Others

  Industry Vertical

  • Hair Care &Treatment
  • Consumer Goods
  • Cosmetics Industry
  • Others

Key Benefits of the Report:

  • This study presents the analytical depiction of the global shampoo industry along with the current trends and future estimations to determine the imminent investment pockets.
  • The report presents information related to key drivers, restraints, and opportunities along with detailed analysis of the global shampoo market share.
  • The current market is quantitatively analyzed from 2020 to 2027 to highlight the global shampoo market growth scenario.
  • Porter’s five forces analysis illustrates the potency of buyers & suppliers in the market.
  • The report provides a detailed global shampoo market analysis based on competitive intensity and how the competition will take shape in the coming years.

Shampoo Market Type

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Hair Transplant Market

Hair Transplant Market

Hair Transplant Market By Surgery Method

This specialized and expertise oriented industry research report scrutinizes the technical and commercial business outlook of the Hair Transplant Industry. The report analyzes and declares the historical and current trends analysis of the Hair Transplant industry and subsequently recommends the projected trends anticipated to be observed in the Hair Transplant market during the upcoming years.

The Hair Transplant market report analyzes and notifies the industry statistics at the global as well as regional and country levels to acquire a thorough perspective of the entire Hair Transplant market. The historical and past insights are provided for FY 2016 to FY 2019 whereas projected trends are delivered for FY 2020 to FY 2026. The quantitative and numerical data is represented in terms of value in USD Million from FY 2016 – 2026.

The quantitative data is further underlined and reinforced by comprehensive qualitative data which comprises various across-the-board market dynamics. The rationales which directly or indirectly impact the Hair Transplant industry are exemplified through parameters such as growth drivers, restraints, challenges, and opportunities among other impacting factors.

Throughout our research report, we have encompassed all the proven models and tools of industry analysis and extensively illustrated all the key business strategies and business models adopted in the Hair Transplant Industry. The report provides an all-inclusive and detailed competitive landscape prevalent in the Hair Transplant market.

The report utilizes established industry analysis tools and models such as Porter’s Five Forces framework to analyze and recognize critical business strategies adopted by various stakeholders involved in the entire value chain of the Hair Transplant Industry. The Hair Transplant market report additionally employs SWOT analysis and PESTLE analysis models for further in-depth analysis.

The report study further includes an in-depth analysis of industry players’ market shares and provides an overview of leading players’ market position in the Hair Transplant sector. Key strategic developments in the Hair Transplant market competitive landscape such as acquisitions & mergers, inaugurations of different products and services, partnerships & joint ventures, MoU agreements, VC & funding activities, R&D activities, and geographic expansion among other noteworthy activities by key players of the Hair Transplant market are appropriately highlighted in the report.

The Hair Transplant market is estimated to develop with healthy CAGR in upcoming years. Hair Transplant has a wide application that leads to the growth of the industry. Nonetheless, lack of knowledge is likely to obstruct the market in the coming years.

The global Hair Transplant market has been segmented on the basis of product, end-user, and application. On the basis of product segment the target market is segmented into Single Follicular Unit Transplantation (FUT), Follicular Unit Extraction (FUE) and Others. On the basis of the application segment, the global market is segmented into Headhair Transplant, Eyebrow Transplant, Frontal Hairline Lowering or Reconstruction and Others. On the basis of end-Users, Market is classified into Hospital, Tricology Clinics, Dermatological Clinics, and Others

Some of the most important market players in the global Hair Transplant market are MEDICAMAT, Restoration Robotics Inc., Cole Instruments Inc., Bernstein Medical, Ethics hair Instruments, Bosley and others

The taxonomy of the Hair Transplant Market by its scope and segmentation is as follows:

Global Hair Transplant Market: Surgery Method Segment Analysis

  • Follicular Unit Transplantation (FUT)
  • Follicular Unit Extraction (FUE)
  • Others

Global Hair Transplant Market: Surgery Type Segment Analysis

  • Headhair Transplant
  • Eyebrow Transplant
  • Frontal Hairline Lowering or Reconstruction
  • Others

Global Hair Transplant Market: End-Users Segment Analysis

  • Hospital
  • Tricology Clinics
  • Dermatlogival Clinics
  • Others

Global Hair Transplant Market: By Region Segment Analysis

  • North America
    • The U.S.
    • Canada
  • Europe
    • Germany
    • France
    • UK
    • Italy
    • Spain
    • Rest Of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • Southeast Asia
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • The Middle East & Africa
    • GCC Countries
    • South Africa
    • Rest of Middle East & Africa

KEY REPORT POINTERS & HIGHLIGHTS:

  • Statistically Validated Analysis of Historical, Current, and Projected Industry Trends with Authenticated Market Sizes Information and Data in terms of Value and Volume, wherever applicable
  • Direct and Indirect Factors that Impacted the Industry as well Projected Rationales expected to affect the industry going forward
  • Micro, Meso, Macro, and In-Depth Analysis of Technically relevant and Commercially viable Segments and Sub-segments of the Market
  • Historical and Projected Company / Vendor / OEM / Supplier Market Shares, Competitive Landscape, and Player Positioning Data
  • Historical and Current Demand (Consumption) and Supply (Production) Scenarios as well as Projected Supply-Demand Scenario Analysis
  • Detailed List of Key Buyers and End-Users (Consumers) analyzed as per Regions and Applications
  • Value Chain and Supply Chain Analysis along with Horizontal and Vertical Integration Scenarios
  • Manufacturing and Production Cost Structure Analysis including Labor Cost, Raw Material Expenses, and Other Manufacturing Expenses, wherever relevant
  • Overview of Key Marketing Strategies and Key Sales Channels Adopted in the Market
  • Market Attractiveness Analysis and Key Investment Opportunity Analysis in the Market going forward
  • Technological Roadmap, Patents Analysis, Potential Substitutes, and Technical Analysis
  • The professionally substantiated market research report study is calculated, constructed, and assembled by implementing a robust research methodology. The triangular process comprises a buoyant mix of exhaustive primary research (focused interviews, questionnaires, and ad-hoc surveys) and extended secondary research (paid external databases, proprietary in-house database, and publically-available validated sources), where it is finally triangulated and validated through in-house industry experts, industry leaders, and independent consultants through a tri-level quality check practice

Hair Transplant Market By Surgery Method

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