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Stem Cell Alopecia Treatment Market

hair loss might be pre­ven­ted by reg­u­lat­ing stem cell meta­bol­ism

A study in­dic­ates that hair loss might be pre­ven­ted by reg­u­lat­ing stem cell meta­bol­ism

An international research group headed by Associate Professor Sara Wickström at the University of Helsinki has identified a mechanism that is likely to prevent hair loss.

Hair follicle stem cells, which promote hair growth, can prolong their life by switching their metabolic state. In experiments conducted with mice, a research group active in Helsinki and Cologne, Germany, has demonstrated that a protein called Rictor holds a key role in the process.

The study was published in the Cell Metabolism journal.

New in­for­ma­tion on mech­an­isms that reg­u­late stem cells

Ultraviolet radiation and other environmental factors damage our skin and other tissues every day, with the body continuously removing and renewing the damaged tissue. On average, humans shed daily 500 million cells and a quantity of hairs weighing a total of 1.5 grams.

The dead material is replaced by specialised stem cells that promote tissue growth. Tissue function is dependent on the activity and health of these stem cells, as impaired activity results in the ageing of the tissues.

“Although the critical role of stem cells in ageing is established, little is known about the mechanisms that regulate the long-term maintenance of these important cells. The hair follicle with its well-understood functions and clearly identifiable stem cells was a perfect model system to study this important question,” says Sara Wickström.

Re­duced meta­bolic flex­ib­il­ity in stem cells un­der­ly­ing hair loss

At the end of hair follicles’ regenerative cycle, the moment a new hair is created, stem cells return to their specific location and resume a quiescent state. The key finding in the new study is that this return to the stem cell state requires a change in the cells’ metabolic state. They switch from glutamine-based metabolism and cellular respiration to glycolysis,a shift triggered by signalling induced by a protein called Rictor, in response to the low oxygen concentration in the tissue.

Correspondingly, the present study demonstrated that the absence of the Rictor protein impaired the reversibility of the stem cells, initiating slow exhaustion of the stem cells and hair loss caused by ageing.

The research group created a genetic mouse model to study the function of the Rictor protein, observing that hair follicle regeneration and cycle were significantly delayed in mice lacking the protein. Ageing mice suffering from Rictor deficiency showed a gradual decrease in their stem cell, resulting in loss of hair.

Pre­curs­ors for de­vel­op­ing hair loss drug ther­apies

Further research will now be conducted to investigate how these preclinical findings could be utilised in human stem cell biology and potentially also in drug therapies that would protect hair follicles from ageing. In other words, the mechanisms identified in the study could possibly be utilised in preventing hair loss.

“We are particularly excited about the observation that the application of a glutaminase inhibitor was able to restore stem cell function in the Rictor-deficient mice, proving the principle that modifying metabolic pathways could be a powerful way to boost the regenerative capacity of our tissues,” Wickström explains.

Further information:

Sara Wickström, MD, PhD, Associate professor at the Helsinki Institute of Life Science, University of Helsinki; research group leader at the Max Planck Institute

A study in­dic­ates that hair loss might be pre­ven­ted by reg­u­lat­ing stem cell meta­bol­ism

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Stem Cell Alopecia Treatment Market

hair loss might be pre­ven­ted by reg­u­lat­ing stem cell meta­bol­ism

A study in­dic­ates that hair loss might be pre­ven­ted by reg­u­lat­ing stem cell meta­bol­ism

An international research group headed by Associate Professor Sara Wickström at the University of Helsinki has identified a mechanism that is likely to prevent hair loss.

Hair follicle stem cells, which promote hair growth, can prolong their life by switching their metabolic state. In experiments conducted with mice, a research group active in Helsinki and Cologne, Germany, has demonstrated that a protein called Rictor holds a key role in the process.

The study was published in the Cell Metabolism journal.

New in­for­ma­tion on mech­an­isms that reg­u­late stem cells

Ultraviolet radiation and other environmental factors damage our skin and other tissues every day, with the body continuously removing and renewing the damaged tissue. On average, humans shed daily 500 million cells and a quantity of hairs weighing a total of 1.5 grams.

The dead material is replaced by specialised stem cells that promote tissue growth. Tissue function is dependent on the activity and health of these stem cells, as impaired activity results in the ageing of the tissues.

“Although the critical role of stem cells in ageing is established, little is known about the mechanisms that regulate the long-term maintenance of these important cells. The hair follicle with its well-understood functions and clearly identifiable stem cells was a perfect model system to study this important question,” says Sara Wickström.

Re­duced meta­bolic flex­ib­il­ity in stem cells un­der­ly­ing hair loss

At the end of hair follicles’ regenerative cycle, the moment a new hair is created, stem cells return to their specific location and resume a quiescent state. The key finding in the new study is that this return to the stem cell state requires a change in the cells’ metabolic state. They switch from glutamine-based metabolism and cellular respiration to glycolysis,a shift triggered by signalling induced by a protein called Rictor, in response to the low oxygen concentration in the tissue.

Correspondingly, the present study demonstrated that the absence of the Rictor protein impaired the reversibility of the stem cells, initiating slow exhaustion of the stem cells and hair loss caused by ageing.

The research group created a genetic mouse model to study the function of the Rictor protein, observing that hair follicle regeneration and cycle were significantly delayed in mice lacking the protein. Ageing mice suffering from Rictor deficiency showed a gradual decrease in their stem cell, resulting in loss of hair.

Pre­curs­ors for de­vel­op­ing hair loss drug ther­apies

Further research will now be conducted to investigate how these preclinical findings could be utilised in human stem cell biology and potentially also in drug therapies that would protect hair follicles from ageing. In other words, the mechanisms identified in the study could possibly be utilised in preventing hair loss.

“We are particularly excited about the observation that the application of a glutaminase inhibitor was able to restore stem cell function in the Rictor-deficient mice, proving the principle that modifying metabolic pathways could be a powerful way to boost the regenerative capacity of our tissues,” Wickström explains.

Further information:

Sara Wickström, MD, PhD, Associate professor at the Helsinki Institute of Life Science, University of Helsinki; research group leader at the Max Planck Institute

A study in­dic­ates that hair loss might be pre­ven­ted by reg­u­lat­ing stem cell meta­bol­ism

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Platelet Rich Plasma and Stem Cell Alopecia Treatment Market

Stem Cell and Platelet Rich Plasma

New informative research on Stem Cell and Platelet Rich Plasma

This report focuses on the global Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies status, future forecast, growth opportunity, key market and key players.

The study objectives are to present the Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies development in North America, Europe, China, Japan, Southeast Asia, India and Central & South America.

The key players covered in this study

Orange County Hair Restoration Center
Hair Sciences Center of Colorado
Anderson Center for Hair
Evolution Hair Loss Institute
Savola Aesthetic Dermatology Center
Virginia Surgical Center
Hair Transplant Institute of Miami
Colorado Surgical Center & Hair Institute

Market segment by Type, the product can be split into

Platelet Rich Plasma Injections
Stem Cell Therapy
Market segment by Application, split into
Dermatology Clinics
Hospitals

Market segment by Regions/Countries, this report covers

North America
Europe
China
Japan
Southeast Asia
India
Central & South America

The study objectives of this report are:

To analyze global Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies status, future forecast, growth opportunity, key market and key players.
To present the Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies development in North America, Europe, China, Japan, Southeast Asia, India and Central & South America.
To strategically profile the key players and comprehensively analyze their development plan and strategies.
To define, describe and forecast the market by type, market and key regions.

In this study, the years considered to estimate the market size of Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies are as follows:
History Year: 2015-2019
Base Year: 2019
Estimated Year: 2020
Forecast Year 2020 to 2026
For the data information by region, company, type and application, 2019 is considered as the base year. Whenever data information was unavailable for the base year, the prior year has been considered.

New informative research on Stem Cell and Platelet Rich Plasma

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Embryonic Stem Cell Injection

Breakthrough Hair Loss Technology With Embryonic Stem Cell Injections

Colorado Surgical & Hair Institute Introduces Breakthrough Hair Loss Technology With Embryonic Stem Cell Injections

Hair restoration experts at the Colorado Surgical & Hair Institute recently announced the breakthrough technology of Embryonic Stem Cell Injections to treat hair loss.

They have the distinction of being one of only three hair loss centers in the United States to offer this revolutionary technology.

The procedure is effective at strengthening existing hair and growing new hair without having a surgical procedure.

Patients can begin to regrow hair in as little as two to fourteen weeks.

According to Lisa Hammond, Medical Director at Colorado Surgical & Hair Institute, “The beauty of this treatment, is that there are no complications, no contradictions, and most importantly, no failures. It works on everyone.”

About Embryonic Stem Cell Injection Therapy:  

The procedure involves BioD Amniotic/Placental ECM (Extracellular Matrix), or BioD Restore. BioD Restore is a human-derived ECM allograft produced from medically screened, sterile harvested cryopreserved donor placental tissue.

Placental tissue is an ECM that is protected from rejection. It stimulates Stem Cells and rejuvenates/repair the skin and hair follicles.

And because BioD is made from a human placenta, it is automatically protected from rejection. So it promotes healing and new growth.

About the Colorado Surgical & Hair Institute:

For more than two and a half decades, the Denver hair transplant experts at Colorado Surgical Center & Hair Institute have assisted thousands of clients restore their scalp and facial hair. They offer high quality hair transplant services at affordable prices.

To learn more about the Colorado Surgical & Hair Institute visit http://www.coloradosurgicalhair.com/

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